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Article

Global Brain Flexibility During Working Memory Is Reduced in a High-Genetic-Risk Group for Schizophrenia.

Biological psychiatry. Cognitive neuroscience and neuroimaging - 1 Dec 2021

Dimitriadis Stavros I, Lancaster Thomas M, Perry Gavin, Tansey Katherine E, Jones Derek K, Singh Krish D, Zammit Stanley, Smith George Davey, Hall Jeremy, O'Donovan Michael C, Owen Michael J, Linden David E

Abstract excerpt

BACKGROUND: Altered functional brain connectivity has been proposed as an intermediate phenotype between genetic risk loci and clinical expression of schizophrenia. Genetic high-risk groups of healthy subjects are particularly suited for the investigation of this proposition because they can be tested in the absence of medication or other secondary effects of schizophrenia. METHODS: Here, we applied dynamic...

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Brain
Genetic Predisposition to Disease
Longitudinal Studies
Memory, Short-Term

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PMID: 33524599
DOI: 10.1016/j.bpsc.2021.01.007
PMCID: PMC7613444

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