Article
Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk.
Cerebral cortex (New York, N.Y. : 1991) - 10 Mar 2023
Dimitriadis S I, Perry G, Lancaster T M, Tansey K E, Singh K D, Holmans P, Pocklington A, Davey Smith G, Zammit S, Hall J, O'Donovan M C, Owen M J, Jones D K, Linden D E
Abstract excerpt
Research studies based on tractography have revealed a prominent reduction of asymmetry in some key white-matter tracts in schizophrenia (SCZ). However, we know little about the influence of common genetic risk factors for SCZ on the efficiency of routing on structural brain networks (SBNs). Here, we use a novel recall-by-genotype approach, where we sample young adults from a population-based cohort (ALSPAC:N...
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