TRAF6 Exerts Tumor-Promoting Effects via Genetic and Autophagic Modulation in Gastric Cancer.

doi:10.1002/mc.70032

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Article

TRAF6 Exerts Tumor-Promoting Effects via Genetic and Autophagic Modulation in Gastric Cancer.

Molecular carcinogenesis - 1 Nov 2025

Zou Yifan, Mao Zhenguang, Xu Jianghao, Wang Weizhi, Wang Zhihao, Dai Jianghong, Zheng Rui, Du Mulong, Zhang Zhengdong

Abstract excerpt

Autophagy plays a multifaceted role in tumorigenesis. However, the association between genetic variants in autophagy and gastric cancer susceptibility remains unclear. We evaluated the association between single-nucleotide polymorphisms (SNPs) of autophagy-related genes and gastric cancer risk using a cohort of 1,625 cases and 2,100 controls. Next, transcriptomic data were used to analyze differential gene...

Read the complete abstract on PubMed

Topics

Humans
Stomach Neoplasms
Autophagy
Male
Female
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

TNF Receptor-Associated Factor 6

Gene Expression Regulation, Neoplastic

Tumor Microenvironment

Prognosis

Middle Aged

Cell Proliferation

Genetic Predisposition to Disease

Cell Line, Tumor

Case-Control Studies

Biomarkers, Tumor

Cell Movement

Intracellular Signaling Peptides and Proteins

Source

Open in PubMed

Identifiers

PMID: 40831237
DOI: 10.1002/mc.70032

Genes

TRAF6

Provenance

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