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Utilizing Multi-omics analysis to elucidate the role of mitochondrial gene defects in Gastric cancer progression

9 Jun 2025

Abstract excerpt

BACKGROUND: Gastric cancer is a leading cause of cancer-related mortality worldwide, with poor survival outcomes despite advances in diagnostic and therapeutic methods. Mitochondrial autophagy, or mitophagy, is crucial for maintaining cellular homeostasis and has significant implications in tumor biology. DUSP1, a bispecific phosphatase regulating MAP kinase activity, has been associated with various cancers, but...

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Autophagy in Disease and Therapy
Ferroptosis and cancer prognosis
Protein Tyrosine Phosphatases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40489463
DOI: 10.1371/journal.pone.0325520

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