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HDAC4 promotes the growth and metastasis of gastric cancer via autophagic degradation of MEKK3

30 May 2022

Abstract excerpt

BACKGROUND: Histone deacetylases (HDACs) have been shown to be involved in tumorigenesis, but their precise role and molecular mechanisms in gastric cancer (GC) have not yet been fully elucidated. METHODS: Bioinformatics screening analysis, qRT-PCR, and immunohistochemistry (IHC) were used to identify the expression of HDAC4 in GC. In vitro and in vivo functional assays illustrated the biological function of...

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Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
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PMID: 35637410
DOI: 10.1038/s41416-022-01805-7

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