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Gene regulatory activity associated with polycystic ovary syndrome revealed DENND1A-dependent testosterone production

18 Aug 2025

Abstract excerpt

Polycystic ovary syndrome (PCOS) is among the most common disorders affecting up to 15% of the menstruating population globally. It is the leading cause of anovulatory infertility and a major risk factor for type 2 diabetes. Elevated testosterone levels are a core endophenotype. Despite that prevalence, the underlying causes remain unknown. PCOS genome-wide association studies (GWAS) have reproducibly mapped a...

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PMID: 40825976
DOI: 10.1038/s41467-025-62884-7

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