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Article

Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype

31 Mar 2014

Abstract excerpt

Polycystic ovary syndrome (PCOS), characterized by increased ovarian androgen biosynthesis, anovulation, and infertility, affects 5-7% of reproductive-age women. Genome-wide association studies identified PCOS candidate loci that were replicated in subsequent reports, including DENND1A, which encodes a protein associated with clathrin-coated pits where cell-surface receptors reside. However, these studies...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 24706793
DOI: 10.1073/pnas.1400574111

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