Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human DENND1A.V2 Drives Cyp17a1 Expression and Androgen Production in Mouse Ovaries and Adrenals

6 Apr 2020

Abstract excerpt

The DENND1A locus is associated with polycystic ovary syndrome (PCOS), a disorder characterized by androgen excess. Theca cells from ovaries of PCOS women have elevated levels of a DENND1A splice variant (DENND1A.V2). Forced expression of this variant in normal theca cells increases androgen biosynthesis and CYP17A1 expression, whereas knockdown of the transcript in PCOS theca cells reduced androgen production...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hormonal and reproductive studies
Share to Ovarian function and disorders
Share to Sexual Differentiation and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32268539
DOI: 10.3390/ijms21072545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human DENND1A.V2 Drives Cyp17a1 Expression and Androgen Production in Mouse Ovaries and AdrenalsPMID 32268539Read ↗

Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotypeSemantic proximity Read ↗

Alternative splicing of DENND1A, a PCOS candidate gene, generates variant 2.Semantic proximity Read ↗

Current concepts of polycystic ovary syndrome pathogenesisSemantic proximity Read ↗

miRNA Profiling Reveals miRNA-130b-3p Mediates DENND1A Variant 2 Expression and Androgen BiosynthesisSemantic proximity Read ↗

Gene regulatory activity associated with polycystic ovary syndrome revealed DENND1A-dependent testosterone productionSemantic proximity Read ↗

Gene regulatory activity associated with PCOS revealed <i>DENND1A</i> -dependent testosterone productionSemantic proximity Read ↗

Family-Based Quantitative Trait Meta-Analysis Implicates Rare Noncoding Variants in DENND1A in Polycystic Ovary SyndromeSemantic proximity Read ↗

Family-based quantitative trait meta-analysis implicates rare noncoding variants in <i>DENND1A</i> in pathogenesis of polycystic ovary syndromeSemantic proximity Read ↗

Genetic alterations within the DENND1A gene in patients with polycystic ovary syndrome (PCOS).Semantic proximity Read ↗

Colocalization of Polycystic Ovary Syndrome Candidate Gene Products in Theca Cells Suggests Novel Signaling PathwaysSemantic proximity Read ↗

DENND1A gene variants in Bahraini Arab women with polycystic ovary syndrome.Semantic proximity Read ↗

Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.