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Article

Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes.

Life science alliance - 1 Oct 2025

Hargreaves Eleanor, Collinson Rebecca, Jenks Andrew D, Staszewski Adina, Tsalikis Athanasios, Bodoque Raquel, Arias-Garcia Mar, Abdi Yasmin, Al-Malki Abdulaziz, Yuan Yinyin, Natrajan Rachael, Haider Syed, Iskratsch Thomas, Wang Won-Jing, Godinho Susana, Palaskas Nicolaos J, Calvo Fernando, Vivanco Igor, Zech Tobias, Tanos Barbara E

Abstract excerpt

Centriole and/or cilium defects are characteristic of cancer cells and have been linked to cancer cell invasion. However, the mechanistic bases of this regulation remain incompletely understood. Spindle assembly abnormal protein 6 homolog (SAS-6) is essential for centriole biogenesis and cilium formation. SAS-6 levels decrease at the end of mitosis and G1, resulting from APCCdh1-targeted degradation. To examine...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40825584
DOI: 10.26508/lsa.202402820
PMCID: PMC12361644

Genes

SASS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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