Article
SBDS expression and localization at the mitotic spindle in human myeloid progenitors.
PloS one - 17 Sept 2009
Orelio Claudia, Verkuijlen Paul, Geissler Judy, van den Berg Timo K, Kuijpers Taco W
Abstract excerpt
BACKGROUND: Shwachman-Diamond Syndrome (SDS) is a hereditary disease caused by mutations in the SBDS gene. SDS is clinically characterized by pancreatic insufficiency, skeletal abnormalities and bone marrow dysfunction. The hematologic abnormalities include neutropenia, neutrophil chemotaxis defects, and an increased risk of developing Acute Myeloid Leukemia (AML). Although several studies have suggested that...
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