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Article

Elucidating the link between NS-SNP-Induced protein conformational changes and drug resistance in Klebsiella pneumoniae.

Archives of microbiology - 21 Jan 2026

Liu Wenjia, Rao Xin

Abstract excerpt

The escalating drug-resistance of Klebsiella pneumoniae (K. pneumoniae), a leading cause of both community-acquired and nosocomial infections, poses a severe threat to global public health. While non-synonymous single nucleotide polymorphisms (NS-SNPs) serve as crucial molecular markers in microbial resistance studies, their role in inducing protein conformational changes to confer resistance in K. pneumoniae...

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PMID: 41563486
DOI: 10.1007/s00203-025-04697-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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