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CircRNAs: functions and emerging roles in cancer and immunotherapy

15 Aug 2025

Abstract excerpt

BACKGROUND: Circular RNAs (circRNAs) are emerging as promising tools in cancer and immunotherapy, with unique characteristics that offer potential therapeutic applications. MAIN BODY: This review outlines the discovery, biogenesis, and mechanisms of circRNAs, emphasizing their roles in cancer and immune regulation. CircRNAs modulate immune responses by acting as miRNA sponges, binding RNA-binding proteins, or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40817061
DOI: 10.1186/s12916-025-04306-5

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