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The structure of the mammalian bornavirus polymerase complex

13 Aug 2025

Abstract excerpt

Borna disease virus 1 (BoDV-1) is a non-segmented RNA virus with one of the smallest known RNA virus genomes. BoDV-1 replicates in the nucleus of infected cells using a virally encoded polymerase complex composed of the large protein and phosphoprotein. Here, we present the BoDV-1 polymerase complex at resolutions up to 2.8 Å, describing the fully ordered large polymerase protein bound to tetrameric...

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PMID: 40804239
DOI: 10.1038/s41467-025-62906-4

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