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Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering

26 Oct 2017

Abstract excerpt

Abstract The phosphoprotein (P) is the main and essential cofactor of the RNA polymerase (L) of non-segmented, negative‐strand RNA viruses. P positions the viral polymerase onto its nucleoprotein–RNA template and acts as a chaperone of the nucleoprotein (N), thereby preventing nonspecific encapsidation of cellular RNAs. The phosphoprotein of human metapneumovirus (HMPV) forms homotetramers composed of a stable...

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PMID: 29093501
DOI: 10.1038/s41598-017-14448-z

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