Article
A three-way interface of the Nipah virus phosphoprotein X-domain coordinates polymerase movement along the viral genome
4 Sept 2024
Abstract excerpt
ABSTRACT Nipah virus (NiV) is a highly pathogenic paramyxovirus causing frequently lethal encephalitis in humans. The NiV genome is encapsidated by the nucleocapsid (N) protein. RNA synthesis is mediated by the viral RNA-dependent RNA polymerase (RdRP), consisting of the polymerase (L) protein complexed with the homo-tetrameric phosphoprotein (P). The advance of the polymerase along its template requires...
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