Article
Nodal Marginal Zone Lymphoma with Prominent Expansion of PD-1+ T-Follicular Helper Cells: A Persistent Diagnostic Challenge with a Heterogeneous Mutational Architecture.
International journal of molecular sciences - 20 Dec 2025
Crisci Stefania, De Chiara Annarosaria, Oro Maria, Rivieccio Maria, Altobelli Annalisa, Mele Sara, Sirica Letizia, Donnarumma Daniela, Bonanni Matteo, Cuccaro Annarosa, Fresa Alberto, De Filippi Rosaria, Pinto Antonio
Abstract excerpt
Nodal marginal zone lymphoma (NMZL) is an indolent B-cell lymphoma that may pose diagnostic challenges due to the absence of distinct markers. In rare atypical cases, an overabundance of PD1+ T follicular helper (TFH) cells in tumor tissue may mimic peripheral T-cell lymphoma (PTCL) of TFH origin, further complicating the diagnosis. A 72-year-old woman with progressive lymphadenopathy had a cervical lymph node...
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