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Article

A molecular mechanism for adrenergic-induced long QT syndrome.

Journal of the American College of Cardiology - 4 Mar 2014

Wu Jie, Naiki Nobu, Ding Wei-Guang, Ohno Seiko, Kato Koichi, Zang Wei-Jin, Delisle Brian P, Matsuura Hiroshi, Horie Minoru

Abstract excerpt

OBJECTIVES: This study sought to explore molecular mechanisms underlying the adrenergic-induced QT prolongation associated with KCNQ1 mutations. BACKGROUND: The most frequent type of congenital long QT syndrome is LQT1, which is caused by mutations in the gene (KCNQ1) that encodes the alpha subunit of the slow component of delayed rectifier K(+) current (IKs) channel. We identified 11 patients from 4 unrelated...

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Source

Identifiers

PMID: 24184248
DOI: 10.1016/j.jacc.2013.08.1648

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A molecular mechanism for adrenergic-induced long QT syndrome.PMID 24184248Read ↗

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