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Article

Ocular Gene Transfer with Self-Complementary AAV Vectors

25 Jun 2007

Abstract excerpt

PURPOSE: Self-complementary AAV (scAAV) vectors have been developed to circumvent rate-limiting second-strand synthesis in single-stranded AAV vector genomes and to facilitate robust transgene expression at a minimal dose. In this study, the authors investigated the effects of intraocular injections of type 2 scAAV.GFP in mice. METHODS: Dose-response experiments were performed to compare conventional...

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Share to Ocular Diseases and Behçet’s Syndrome
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PMID: 17591905
DOI: 10.1167/iovs.06-1306

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