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Article

Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina

5 Sept 2017

Abstract excerpt

There is much debate on the adeno-associated virus (AAV) serotype that best targets specific retinal cell types and the route of surgical delivery-intravitreal or subretinal. This study compared three of the most efficacious AAV vectors known to date in a mouse model of retinal degeneration (rd1 mouse) and macaque and human retinal explants. Green fluorescent protein (GFP) driven by a ubiquitous promoter was...

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PMID: 28872643
DOI: 10.1038/gt.2017.85

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