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Article

Proteome-Wide Mendelian Randomization Identifies Natriuretic Peptide-B and Novel Proteins as Potential Regulators of Pulse Pressure in Humans.

Journal of the American Heart Association - 19 Aug 2025

Dib Marie-Joe, Meena Devendra, Yarmolinsky James, Azzo Joe D, Salman Oday, Tavolinejad Hamed, Gan Sushrima, Beeche Cameron, Pourmussa Bianca, Gill Dipender, Burgess Stephen, Chirinos Julio A

Abstract excerpt

BACKGROUND: Large-artery stiffness (LAS) significantly contributes to cardiovascular morbidity and death and is characterized by increased pulse pressure (PP). The biology underlying large-artery stiffness in humans remains incompletely understood. METHODS AND RESULTS: We investigated associations between PP and circulating levels of 2941 proteins among 53 016 UK Biobank participants. Analyses were adjusted for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40792569
DOI: 10.1161/JAHA.124.037596
PMCID: PMC7618058

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NPPB

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