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Acute Promyelocytic Leukemia: Pathophysiology, Diagnosis and Clinical Management

2025-09-22

Abstract excerpt

<h4>Background: </h4> /Objectives: Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by the t(15;17)(q24;q21) translocation, generating the PML-RARα fusion gene that blocks myeloid differentiation and drives leukemogenesis. Despite advances in therapy, early mortality remains a major challenge due to severe coagulopathy. This review aims to summarize recent insights i...

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Literature Corpus work
6f56f944-d314-53cc-9fd1-e3e5f9e5a50d
DOI
10.20944/preprints202509.1802.v1
Open publication

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Acute Promyelocytic Leukemia: Pathophysiology, Diagnosis and Clinical ManagementDOI 10.20944/preprints202509.1802.v1
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