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Article

In Lower-Grade Gliomas, the SPARC Family Exacerbates Prognosis by Influencing Immunity, Stemness, and Metabolism.

Cancer reports (Hoboken, N.J.) - 1 Aug 2025

Peng Qiaoying, Zhou Wenxia, Chen Ying, Cai Yong

Abstract excerpt

BACKGROUND: Involvement of the SPARC stromal protein family in crucial biological regulatory mechanisms is well-documented. But understanding the consequences of imbalanced SPARC protein activity in lower-grade glioma (LGG) is still emerging. AIMS: Examining the clinical significance of SPARC proteins, researchers employed RNA-seq data from diverse patient groups to gain insight. A novel SPARCScore was developed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40781854
DOI: 10.1002/cnr2.70307
PMCID: PMC12334845

Genes

SPARC
GSC
EGFR
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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