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Integrated single-cell and bulk RNA-sequencing data reveal prognosis and therapeutic response in low-grade glioma based on hypoxia-lactylation related genes

25 Aug 2025

Abstract excerpt

BACKGROUND: The prognosis of low-grade glioma (LGG) exhibits significant heterogeneity, and the optimal management strategy remains controversial. Therefore, identifying biomarkers associated with glioma prognosis is necessary. METHODS: Hub genes were identified and a prognostic risk signature was constructed in the TCGA cohort using LASSO Cox regression. The predictive significance of this model was assessed and...

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Ferroptosis and cancer prognosis
Glioma Diagnosis and Treatment
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40853584
DOI: 10.1007/s12672-025-03459-2

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