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Article

DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling

31 Aug 2018

Abstract excerpt

Epigenetic alterations play an important role in the pathogenesis in multiple myeloma, but their biological and clinical relevance is not fully understood. Here, we show that DOT1L, which catalyzes methylation of histone H3 lysine 79, is required for myeloma cell survival. DOT1L expression levels were higher in monoclonal gammopathy of undetermined significance and smoldering multiple myeloma than in normal...

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PMID: 30171029
DOI: 10.3324/haematol.2018.191262

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