Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering the interplay between SGLT2 inhibition, CCL4, and angina pectoris: A Mendelian randomization study.

Medicine - 31 Jul 2026

Zhang Yujia, Zhao Yukai, Dong Zheng, Gao Yuan, Wan Dongmei

Abstract excerpt

Angina pectoris, a key symptom of coronary artery disease, is closely associated with inflammation. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown cardiovascular benefits, but their exact mechanisms, particularly regarding inflammation, are not fully understood. This study used Mendelian Randomization (MR) to investigate whether SGLT2 inhibition reduces angina risk by modulating inflammatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angina Pectoris
Share to Chemokine CCL4
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCL4 gene

Share to Genome-Wide Association Study

Share to Inflammation

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42536579
DOI: 10.1097/MD.0000000000050078
PMCID: PMC13433048

Genes

CCL4
SLC5A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering the interplay between SGLT2 inhibition, CCL4, and angina pectoris: A Mendelian randomization study.PMID 42536579Read ↗

Genetic insights into SGLT2 inhibition and atrial fibrillation: exploring the mediating role of inflammatory proteins.Semantic proximity Read ↗

SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study.Semantic proximity Read ↗

SGLT2 inhibition, high-density lipoprotein cholesterol and aortic aneurysm: A drug-target Mendelian randomization study.Semantic proximity Read ↗

SGLT2 inhibition, circulating metabolites, and atrial fibrillation: a Mendelian randomization study.Semantic proximity Read ↗

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.Semantic proximity Read ↗

Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study.Semantic proximity Read ↗

Elucidating Genetic and Immunological Pathways Mediated by Sodium-Glucose Transporter 2 Inhibitors in Reducing Gout Risk: A Two-Step Mendelian Randomization Study.Semantic proximity Read ↗

Exploring the therapeutic potential of interleukin-6 receptor blockade in cardiovascular disease treatment through Mendelian randomization.Semantic proximity Read ↗

Causal association between gastrointestinal diseases and coronary artery disease: a bidirectional Mendelian randomization study.Semantic proximity Read ↗

Decoding Restenosis Risk After CABG: A Combined Transcriptomic and Mendelian Randomization AnalysisSemantic proximity Read ↗

The effect of SGLT2 inhibition on immune cells and transplant rejection/failure: A drug-targeted mendelian randomization study.Semantic proximity Read ↗

Causal role of circulating inflammatory proteins in Angina pectoris: a bidirectional Mendelian randomization study with mediator insightsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.