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SPP1 regulates alveolar type 2 cell-macrophage cross talk and epithelial cell fate in iron-driven lung fibrosis

6 Aug 2025

Abstract excerpt

This study reveals a novel mechanism linking iron dysregulation to pulmonary fibrosis through SPP1-mediated reprogramming of alveolar type 2 cells. We demonstrate SPP1’s dual role: externally coordinating macrophage recruitment and internally directing pathological epithelial transitions toward a Krt8 + intermediate state. These findings, validated across multiple mouse models and human specimens, identify the...

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Share to Extracellular vesicles in disease
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Iron Metabolism and Disorders

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PMID: 40767540
DOI: 10.1152/ajpcell.00140.2025

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