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Article

Ironing Out the Details: How Iron Orchestrates Macrophage Polarization.

Frontiers in immunology - 1 Jan 2021

Xia Yaoyao, Li Yikun, Wu Xiaoyan, Zhang Qingzhuo, Chen Siyuan, Ma Xianyong, Yu Miao

Abstract excerpt

Iron fine-tunes innate immune responses, including macrophage inflammation. In this review, we summarize the current understanding about the iron in dictating macrophage polarization. Mechanistically, iron orchestrates macrophage polarization through several aspects, including cellular signaling, cellular metabolism, and epigenetic regulation. Therefore, iron modulates the development and progression of multiple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34054839
DOI: 10.3389/fimmu.2021.669566
PMCID: PMC8149954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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