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Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosis

21 Apr 2023

Abstract excerpt

BACKGROUND: Idiopathic Pulmonary Fibrosis (IPF) is an age-associated progressive lung disease with accumulation of scar tissue impairing gas exchange. Previous high-throughput studies elucidated the role of cellular heterogeneity and molecular pathways in advanced disease. However, critical pathogenic pathways occurring in the transition of fibroblasts from normal to profibrotic have been largely overlooked....

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Share to Chronic Obstructive Pulmonary Disease (COPD) Research
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PMID: 37085855
DOI: 10.1186/s12931-023-02419-0

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