Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.

doi:10.1017/S0033291725101037

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Article

Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.

Psychological medicine - 5 Aug 2025

Skelton Megan, Mundy Jessica, Ter Kuile Abigail R, Adey Brett N, Armour Chérie, Buckman Joshua E J, Coleman Jonathan R I, Davies Molly R, Hirsch Colette R, Hotopf Matthew, Jones Ian R, Kalsi Gursharan, Krebs Georgina, Lee Sang Hyuck, Lin Yuhao, McIntosh Andrew M, Peel Alicia J, Rayner Christopher, Rimes Katharine A, Smith Daniel J, Thompson Katherine N, Veale David, Walters James T R, Hübel Christopher, Breen Gerome, Eley Thalia C

Abstract excerpt

BACKGROUND: Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairment are partially distinct, functional impairment is often overlooked. To assess whether functional impairment captures diagnostically relevant genetic liability beyond that of...

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PMID: 40759531
DOI: 10.1017/S0033291725101037
PMCID: PMC12341029

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