Article

Integrated proteomics analysis in cerebrospinal fluid and saliva reveals the changes of endopeptidase activity in Parkinson`s disease

2023-08-14

Abstract excerpt

<title>Abstract</title> <p>Background The prodromal phase of Parkinson's disease can reach 10–20 years, and clinically meaningful biomarkers associated with Parkinson's disease (PD) have not been developed based on biofluid samples. Here, we aimed to identify novel biofulid candidate biomarkers by integrating CSF and saliva proteomes in PD. Methods We used a high-throughput tandem mass spectrometry to analyze 1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cf2a383-d7de-51c1-a7b8-f8b10b587cbf
DOI: 10.21203/rs.3.rs-3091888/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated proteomics analysis in cerebrospinal fluid and saliva reveals the changes of endopeptidase activity in Parkinson`s diseaseDOI 10.21203/rs.3.rs-3091888/v1Read

Discovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysisSemantic proximity Read

Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson’s diseaseSemantic proximity Read

Plasma acellular transcriptome contains Parkinson’s disease signatures that can inform clinical diagnosisSemantic proximity Read

Changes in the cerebrospinal fluid proteome precede and stratify the course of Parkinson’s DiseaseSemantic proximity Read

SWATH Mass Spectrometry-Based CSF Proteome Profile of GBA-Linked Parkinson’s Disease PatientsSemantic proximity Read

Urinary proteome profiling for stratifying patients with familial Parkinson’s diseaseSemantic proximity Read

Cerebrospinal fluid proteomics implicates the granin family in Parkinson’s diseaseSemantic proximity Read

Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid using mass spectrometry-based proteomicsSemantic proximity Read

Cross-sectional proteomic expression in Parkinson's disease-related proteins in drug-naïve patients vs healthy controls with longitudinal clinical follow-upSemantic proximity Read

Integrative Analysis of Gene Expression Profiles of Substantia Nigra Identifies Potential Diagnosis Biomarkers in Parkinson's diseaseSemantic proximity Read

WGCNA and multiple machine learning methods identified SV2C and DENR as novel biomarkers for Parkinson's diseaseSemantic proximity Read

Cholesterol homeostasis and oxidative stress-related novel plasma biomarkers for MSA patientsSemantic proximity Read