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Article

In silico prioritization and further functional characterization of SPINK1 intronic variants.

Human genomics - 4 May 2017

Zou Wen-Bin, Wu Hao, Boulling Arnaud, Cooper David N, Li Zhao-Shen, Liao Zhuan, Chen Jian-Min, Férec Claude

Abstract excerpt

BACKGROUND: SPINK1 (serine protease inhibitor, kazal-type, 1), which encodes human pancreatic secretory trypsin inhibitor, is one of the most extensively studied genes underlying chronic pancreatitis. Recently, based upon data from qualitative reverse transcription-PCR (RT-PCR) analyses of transfected HEK293T cells, we concluded that 24 studied SPINK1 intronic variants were not of pathological significance, the...

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Identifiers

PMID: 28472998
DOI: 10.1186/s40246-017-0103-9
PMCID: PMC5418720

Genes

SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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