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Article

Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2024

Saadmaan Gazi, Dalmasso Maria Carolina, Ramirez Alfredo, Hiltunen Mikko, Kemppainen Nina, Lehtisalo Jenni, Mangialasche Francesca, Ngandu Tiia, Rinne Juha, Soininen Hilkka, Stephen Ruth, Kivipelto Miia, Solomon Alina

Abstract excerpt

INTRODUCTION: We assessed a genetic risk score for Alzheimer's disease (AD-GRS) and apolipoprotein E (APOE4) in an exploratory neuroimaging substudy of the FINGER trial. METHODS: 1260 at-risk older individuals without dementia were randomized to multidomain lifestyle intervention or health advice. N = 126 participants underwent magnetic resonance imaging (MRI), and N = 47 positron emission tomography (PET) scans...

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Identifiers

PMID: 38647197
DOI: 10.1002/alz.13843
PMCID: PMC11180864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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