Article

DPP9-mediated inflammasome repression protects against checkpoint inhibitor lung toxicity

2026-07-03

Abstract excerpt

Over one million patients receive cancer immunotherapy annually, yet the mechanisms underlying life-threatening immune-mediated toxicities remain poorly understood. Checkpoint inhibitor pneumonitis (CIP) is the leading cause of immunotherapy-related mortality, with a case fatality rate approaching 10%, and no genetic risk factors have been described to date. We identified Dipeptidyl-peptidase 9 (DPP9) as the first...

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Literature Corpus work: dcb22f4e-366e-533a-b141-2fb1588a566d
DOI: 10.64898/2026.06.30.735609

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