Analysis of Oncogene Mutations in Odontogenic Myxoma.

doi:10.1016/j.modpat.2025.100856

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Article

Analysis of Oncogene Mutations in Odontogenic Myxoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2025

Pankam Jintana, Kitkumthorn Nakarin, Khovidhunkit Siribang-On Piboonniyom, Bumalee Dusit, Lapthanasupkul Puangwan

Abstract excerpt

Odontogenic myxoma (OM) is a rare, benign mesenchymal odontogenic tumor. Presently, the molecular mechanisms underlying OM remain unclear, and no diagnostic markers have been identified. This study aimed to investigate gene mutations related to the MAPK/ERK, PI3K/mTOR, and β-catenin/Wnt pathways in OM, including KRAS, PIK3CA, and CTNNB1, and their associated proteins. Additionally, the association between gene...

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Topics

Humans
Female
Odontogenic Tumors
Mutation
Male
Adult
beta Catenin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Class I Phosphatidylinositol 3-Kinases

Middle Aged

Proto-Oncogene Proteins p21(ras)

Young Adult

Adolescent

Myxoma

DNA Mutational Analysis

Phosphatidylinositol 3-Kinases

Aged

Biomarkers, Tumor

Child

Source

Open in PubMed

Identifiers

PMID: 40738323
DOI: 10.1016/j.modpat.2025.100856

Genes

CTNNB1
KRAS
PIK3CA

Variants

Provenance

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