Article
Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis.
International journal of oral science - 25 Apr 2022
Togni Lucrezia, Zizzi Antonio, Mazzucchelli Roberta, Santarelli Andrea, Rubini Corrado, Mascitti Marco
Abstract excerpt
Odontogenic tumors are rare lesions with unknown etiopathogenesis. Most of them are benign, but local aggressiveness, infiltrative potential, and high recurrence rate characterize some entities. The MAP-kinase pathway activation can represent a primary critical event in odontogenic tumorigenesis. Especially, the BRAF V600E mutation has been involved in 80-90% of ameloblastic lesions, offering a biological...
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