Genetic Inference of On-target and Off-target Side-effects of Antipsychotic Medications

Abstract excerpt

<title>Abstract</title> <p>Adverse side-effects are the primary cause of antipsychotic drug discontinuation rather than poor efficacy. It is often difficult to ascertain whether patient-reported side-effects are caused by a drug, and if so, through which mechanism. Using a novel genetic method we have devised, we investigated evidence of causality and mechanism for 105 reported side-effects of 6 commonly prescrib...

Topics

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• Antidepressive Agents, Second-Generation
• Citalopram
• Depressive Disorder, Major
• Factor Analysis, Statistical
• Genetic Variation
• Genome-Wide Association Study
• Pharmacogenetics
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

082dee9a-2c22-5b93-a325-9db6a5a25005

DOI

10.21203/rs.3.rs-4570917/v1