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Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection

27 Apr 2022

Abstract excerpt

Zoonotic transmission of coronaviruses poses an ongoing threat to human populations. Endemic outbreaks of swine acute diarrhea syndrome coronavirus (SADS-CoV) have caused severe economic losses in the pig industry and have the potential to cause human outbreaks. Currently, there are no vaccines or specific antivirals against SADS-CoV, and our limited understanding of SADS-CoV host entry factors could hinder...

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PMID: 35476513
DOI: 10.1073/pnas.2118126119

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