Article
SUDEP risk is influenced by longevity genomics: a polygenic risk score study.
EBioMedicine - 1 Aug 2025
Martins Helena, Mills James D, Pagni Susanna, Gulcebi Medine I, Vakrinou Angeliki, Moloney Patrick B, Clayton Lisa M, Bellampalli Ravishankara, Stamberger Hannah, Weckhuysen Sarah, Striano Pasquale, Zara Federico, Bagnall Richard D, Harris Rebekah V, Lawrence Kate M, Sadleir Lynette G, Crompton Douglas E, Friedman Daniel, Laze Juliana, Li Ling, Berkovic Samuel F, Semsarian Christopher, Scheffer Ingrid E, Devinsky Orrin, Kuchenbaecker Karoline, Balestrini Simona, Sisodiya Sanjay M
Abstract excerpt
BACKGROUND: Sudden Unexpected Death in Epilepsy (SUDEP) is a rare and tragic outcome in epilepsy, identified by those with the condition as their most serious concern. Although several clinical factors are associated with elevated SUDEP risk, mechanisms underlying SUDEP are poorly understood, making individual risk prediction challenging, especially early in the disease course. We hypothesised that common genetic...
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