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Article

SUDEP risk is influenced by longevity genomics: a polygenic risk score study

28 Jul 2025

Abstract excerpt

BACKGROUND: Sudden Unexpected Death in Epilepsy (SUDEP) is a rare and tragic outcome in epilepsy, identified by those with the condition as their most serious concern. Although several clinical factors are associated with elevated SUDEP risk, mechanisms underlying SUDEP are poorly understood, making individual risk prediction challenging, especially early in the disease course. We hypothesised that common genetic...

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PMID: 40731221
DOI: 10.1016/j.ebiom.2025.105841

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