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Article

Global white matter microstructural abnormalities associated with addiction liability score in drug naïve youth.

Brain imaging and behavior - 1 Feb 2018

Hulvershorn Leslie, Hummer Tom, Wu Yu-Chien, Tarter Ralph, Rea Parker, Anand Amit, Andrew Chambers R, Finn Peter

Abstract excerpt

Abnormalities in brain white matter (WM) structure have been reported in youths having a family history of substance use disorders (SUDs). It was hypothesized that these abnormalities constitute features of the liability for SUDs transmitted across generations. The association between severity of intergenerational risk for SUD, measured by the Transmissible Liability Index (TLI), and white matter microstructure...

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Identifiers

PMID: 28271440
DOI: 10.1007/s11682-017-9679-x
PMCID: PMC5648640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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