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Article

Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity.

AIDS (London, England) - 19 Jun 2018

Chung Amy W, Mabuka Jenniffer M, Ndlovu Bongiwe, Licht Anna, Robinson Hannah, Ramlakhan Yathisha, Ghebremichael Musie, Reddy Tarylee, Goulder Philip J R, Walker Bruce D, Ndung'u Thumbi, Alter Galit

Abstract excerpt

OBJECTIVE: Postinfection HIV viral control and immune correlates analysis of the RV144 vaccine trial indicate a potentially critical role for Fc receptor-mediated antibody functions. However, the influence of functional antibodies in clade C infection is largely unknown. DESIGN: Plasma samples from 361 chronic subtype C-infected, antiretroviral therapy-naive participants were tested for their HIV-specific isotype...

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Share to Antibody-Dependent Cell Cytotoxicity
Share to Cell Degranulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Antibodies

Share to HIV Core Protein p24

Share to Immunoglobulin G

Share to Killer Cells, Natural

Share to Phagocytosis

Share to Receptors, Fc

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Identifiers

PMID: 29620716
DOI: 10.1097/QAD.0000000000001812
PMCID: PMC5980776

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