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Article

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody

16 Dec 2019

Abstract excerpt

Broadly neutralizing antibodies (bNAbs) protect against HIV infection in non-human primates and their efficacy may be enhanced through interaction with Fc receptors on immune cells. Antibody isotype is a modulator of this binding with the IgG3 subclass mediating potent Fc effector function and is associated with HIV vaccine efficacy and HIV control. BNAb functions are typically assessed independently of the...

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PMID: 31841557
DOI: 10.1371/journal.ppat.1008064

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