Article
Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2016
Huang Yunda, Ferrari Guido, Alter Galit, Forthal Donald N, Kappes John C, Lewis George K, Love J Christopher, Borate Bhavesh, Harris Linda, Greene Kelli, Gao Hongmei, Phan Tran B, Landucci Gary, Goods Brittany A, Dowell Karen G, Cheng Hao D, Bailey-Kellogg Chris, Montefiori David C, Ackerman Margaret E
Abstract excerpt
Diverse Ab effector functions mediated by the Fc domain have been commonly associated with reduced risk of infection in a growing number of nonhuman primate and human clinical studies. This study evaluated the anti-HIV Ab effector activities in polyclonal serum samples from HIV-infected donors, VAX004 vaccine recipients, and healthy HIV-negative subjects using a variety of primary and cell line-based assays,...
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