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Article

Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study.

American journal of human genetics - 7 Aug 2025

Sutoh Yoichi, Hachiya Tsuyoshi, Otsuka-Yamasaki Yayoi, Komaki Shohei, Minabe Shiori, Ohmomo Hideki, Tanno Kozo, Hozawa Atsushi, Nakaya Naoki, Noda Aoi, Orui Masatsugu, Ishikuro Mami, Obara Taku, Kuriyama Shinichi, Sasaki Makoto, Shimizu Atsushi

Abstract excerpt

The atopic march lacks early identification methods for high-risk children. In this study, we assessed whether the risk of atopic diseases in infants could be predicted using a polygenic score (PGS) for total immunoglobulin E (IgE) levels. The PGS estimated using the polygenic model generated by PRS-CS was significantly correlated with log-transformed IgE levels (ρ = 0.200, p < 2.2 × 10-16). Assessment of the...

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Identifiers

PMID: 40695273
DOI: 10.1016/j.ajhg.2025.06.015
PMCID: PMC12414674

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