Article
Dynamics of Deleterious Mutations and Purifying Selection in Small Population Isolates.
Molecular biology and evolution - 1 Jul 2025
Chen Ying, Feng Xueyun, Reid Kerry, Zhang Chaowei, Löytynoja Ari, Merilä Juha
Abstract excerpt
The genomic consequences of prolonged population decline and isolation are increasingly recognized, but quantitative assessments of mutation loads have been limited by low population-level replication in individual studies. Moreover, how inbreeding and purifying selection shape the genomic landscape of deleterious variation remains poorly understood. We evaluated the abundance and frequency of putative...
Read the complete abstract on PubMedTopics
- Selection, Genetic
- Animals
- Mutation
- Inbreeding
- Smegmamorpha
- Homozygote
- Genetics, Population