Article
Genomic evidence for inbreeding depression and purging of deleterious genetic variation in Indian tigers.
Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2021
Khan Anubhab, Patel Kaushalkumar, Shukla Harsh, Viswanathan Ashwin, van der Valk Tom, Borthakur Udayan, Nigam Parag, Zachariah Arun, Jhala Yadavendradev V, Kardos Marty, Ramakrishnan Uma
Abstract excerpt
Increasing habitat fragmentation leads to wild populations becoming small, isolated, and threatened by inbreeding depression. However, small populations may be able to purge recessive deleterious alleles as they become expressed in homozygotes, thus reducing inbreeding depression and increasing population viability. We used whole-genome sequences from 57 tigers to estimate individual inbreeding and mutation load...
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