Article
Revealing extensive inbreeding and less efficient purging of deleterious mutations in wild Amur tigers in China.
Journal of genetics and genomics = Yi chuan xue bao - 1 May 2025
Lan Tianming, Li Haimeng, Liu Boyang, Shi Minhui, Tian Yinping, Sahu Sunil Kumar, Cui Liangyu, Dussex Nicolas, Liu Dan, Ma Yue, Kong Weiyao, Liu Shanlin, Fan Jiale, Zhao Yue, Fu Yuan, Li Qiye, Lin Chen, Dalén Love, Liu Huan, Zhang Le, Jiang Guangshun, Xu Yanchun
Abstract excerpt
Inbreeding increases genome homozygosity within populations, which can exacerbate inbreeding depression by exposing homozygous deleterious alleles that are responsible for declines in fitness traits. In small populations, genetic purging that occurs under the pressure of natural selection acts as an opposing force, contributing to a reduction of deleterious alleles. Both inbreeding and genetic purging are...
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