Article
Integrative Analysis Uncover the Effects and Multi-Omics Features of Thigh Muscle Fat Infiltration.
Aging cell - 1 Sept 2026
Zhang Yiwei, Dang Qin, Zong Xizeng, Chen Haowei, Wen Simin, Xu Siqi, Wang Kunyan, Wang Xiaoshuai, Zhu Jianwei, Zhu Zhaohua, Ding Changhai, Ruan Guangfeng, Zhang Yan
Abstract excerpt
The health impacts and underlying biological pathways of thigh muscle fat infiltration (TMFI) remain incompletely understood. In this study, we analyzed TMFI measured by magnetic resonance imaging in 55,120 UK Biobank participants and found that higher TMFI was significantly associated with all-cause mortality as well as with all major system-specific diseases examined (p values ranged from 2.50 × 10-88 to...
Read the complete abstract on PubMedTopics
- Humans
- Multiomics
- Genome-Wide Association Study
- Female
- Male
- Polymorphism, Single Nucleotide