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Article

Comprehensive Genomic Profiling of Anaplastic Thyroid Cancer Identifies Alterations in THRA, a Potential Modifier of Cellular Plasticity.

JCO global oncology - 1 Jul 2025

Trivedi Vaishakhi, Noronha Vanita, Bal Munita, Chandrani Pratik, Poojary Disha, Saldanha Elveera, Choughule Anuradha, Pange Priyanka, Gupta Vinod, Menon Nandini, Patil Vijay, Shah Minit, Chaturvedi Pankaj, Prabhash Kumar, Dutt Amit

Abstract excerpt

PURPOSE: Lineage-specific cellular plasticity is one of the emerging hallmarks of cancer. The undifferentiated state of anaplastic thyroid cancer (ATC) represents an instance of cellular plasticity where lineage-specific molecular markers are underacknowledged. In this study, we identified recurrent mutations in the thyroid hormone receptor α (THRA) gene, which may play a role in lineage-specific cellular...

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Source

Identifiers

PMID: 40674659
DOI: 10.1200/GO-24-00610

Genes

THRA
TP53
AKT1
BRAF
HRAS
KRAS
NF1
NRAS

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