Genetic mutations disrupt the coordinated mode of tyrosinase's intra-melanosomal domain.

Abstract excerpt

Oculocutaneous albinism type 1 is a genetic disorder caused by the disruption of tyrosinase activity in the melanogenesis pathway. The tyrosinase's intramelanosomal domain can be subdivided into the catalytic and Cys-rich subdomains, integral for protein stability and catalytic activity. To understand the movement in the tyrosinase intra-melanosomal subdomains and their link to its catalytic activity, we perform...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Albinism, Oculocutaneous
• Share to Melanosomes
• Share to Molecular Dynamics Simulation