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Article

Insights from Computational Dynamic Active Site Mapping into Substrate Recognition and Mutation-Induced Dysfunction in Human Tyrosinase.

International journal of molecular sciences - 18 Feb 2026

Dolinska Monika B, Sergeev Yuri V

Abstract excerpt

The ability of enzymes to recognize and process structurally diverse substrates is fundamental to metabolic flexibility and biological regulation. In melanin biosynthesis, human tyrosinase (Tyr) catalyzes the oxidation of several chemically distinct intermediates, including L-tyrosine, L-DOPA, DHICA, and DHI. Although its catalytic chemistry is well established, the structural basis of substrate selectivity and...

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Identifiers

PMID: 41752073
DOI: 10.3390/ijms27041937
PMCID: PMC12940576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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